NEWS
Vinblastine Sulfate
  • Approved Drug Name
    Vinblastine Sulfate
  • CAS NO.
    143-67-9
  • Quality Standard
    USP, EP, CP
  • Packaging
    50G/Bag, 100G/Bag
  • Storage Condition
    Shading,Sealing,Cryopreservation (Below-20℃)
  • Certification
    Ongoing registration

What does Vinblastine Sulfate(casno.143-67-9) used for:
This drug is given to treat Hodgkin lymphoma, non-Hodgkin's lymphoma, testicular, breast, lung (Non-small cell lung cancer), head and neck, and bladder cancers, melanoma, soft tissue sarcoma, Kaposi's sarcoma, mycosis fungoides (t-cell lymphoma), and choriocarcinoma. It can be used to treat fibromatosis and germ cell tumour.
It is also used in the treatment of certain blood disorders such as histiocytosis
Note: If a drug has been approved for one use, physicians may elect to use this same drug for other problems if they believe it may be helpful.
How Vinblastine Sulfate(casno.143-67-9) is given:
Vinblastine Sulfate(casno.143-67-9) is given through a vein by intravenous injection (IV push) or infusion (IV). There is no pill form.
Vinblastine Sulfate(casno.143-67-9) is a vesicant. A vesicant is a chemical that causes extensive tissue damage and blistering if it escapes from the vein. The nurse or doctor who gives this drug must be carefully trained. If you notice pain, redness or swelling at the IV site while you are receiving Vinblastine Sulfate(casno.143-67-9), alert your health care professional immediately.
The amount of Vinblastine Sulfate(casno.143-67-9) you will receive depends on many factors, including your height and weight, your general health or other health problems, and the type of cancer or condition being treated. Your doctor will determine your dose and schedule.
Vinblastine Sulfate(casno.143-67-9) Side effects:
Important things to remember about the side effects of Vinblastine Sulfate(casno.143-67-9) include:
Most people do not experience all of the Vinblastine Sulfate(casno.143-67-9) side effects listed.
Vinblastine Sulfate(casno.143-67-9)'s side effects are often predictable in terms of their onset and duration.
Vinblastine Sulfate(casno.143-67-9)'s side effects should improve after treatment is complete.
Vinblastine Sulfate(casno.143-67-9)'s side effects are usually quite manageable. There are many options to help minimize or prevent the side effects of Vinblastine Sulfate(casno.143-67-9).
The following side effects are common (occurring in greater than 30%) for patients taking Vinblastine Sulfate(casno.143-67-9):
Low blood counts. Your white and red blood cells and platelets may temporarily decrease. This can put you at increased risk for infection, anemia and/or bleeding.
Injection site reactions
Fatigue, and weakness
The following are less common side effects (occurring in 10-29%) for patients receiving Vinblastine Sulfate(casno.143-67-9):
Nausea and vomiting - usually moderate and occur within the first 24 hours of treatment
Poor appetite
Peripheral neuropathy (numbness in your fingers and toes) may occur with repeated doses. This should be reported to your healthcare provider.
Constipation may occur within 1-3 days after your treatment , and is sometimes accompanied by abdominal cramping. It is important to keep your bowels moving regularly.
Diarrhea
Fever
Hair loss may occur, but your hair will most likely grow back when the treatments are completed. This usually begins 2-3 weeks after each treatment.
Hearing loss
Mouth sores
Taste changes, metallic taste
Headache
Depression
Jaw pain, bone pain, tumor pain
High blood pressure (hypertension)
Tiredness
Shortness of breath, myalgias (muscle pain), and arthralgias (joint pain) may occur infrequently
A very serious side effect that is preventable with proper administration technique and immediate treatment is called extravasation, or the leakage of medication out of the veins and into the body. Vinblastine Sulfate(casno.143-67-9) is a vesicant agent and needs to be given in the proper needle or a central catheter. This is important so that the chemotherapy stays within the veins and avoids irritation. If extravasation does occur, there are management techniques to prevent harm. Some nurses are specialized in giving this medication. There are treatment options if extravasation does occur.
Not all side effects are listed above, some that are rare (occurring in less than 10% of patients) are not listed here. However, you should always inform your health care provider if you experience any unusual symptoms.
Precautions of Vinblastine Sulfate(casno.143-67-9):
Before starting Vinblastine Sulfate(casno.143-67-9) treatment, make sure you tell your doctor about any other medications you are taking (including prescription, over-the-counter, vitamins, herbal remedies, etc.).
Do not receive any kind of immunization or vaccination without your doctor's approval while taking Vinblastine Sulfate(casno.143-67-9).
Inform your health care professional if you are pregnant or may be pregnant prior to starting this treatment. Pregnancy category D (Vinblastine Sulfate(casno.143-67-9) may be hazardous to the fetus. Women who are pregnant or become pregnant must be advised of the potential hazard to the fetus).
For both men and women: Do not conceive a child (get pregnant) while taking Vinblastine Sulfate(casno.143-67-9). Barrier methods of contraception, such as condoms, are recommended. Discuss with your doctor when you may safely become pregnant or conceive a child after therapy.
Do not breast feed while taking this medication.
Self-care Tips of Vinblastine Sulfate(casno.143-67-9):
Apply warm compress if you have any pain, redness or swelling at the IV site, and notify your doctor.
Keep your bowels moving. Your health care provider may prescribe a stool softener to help prevent constipation that may be caused by this medicine.
If you experience diarrhea of greater than 4-6 stools per day, contact your healthcare provider and increase your fluid intake.
Drink at least 2 to 3 quarts of fluid every 24 hours, unless you were stold to restrict your fluid intake, and maintain good nutrition. This will decrease your chances of being constipated, and prevent dehydration.
You may be at risk of infection so try to avoid crowds or people with colds, and report fever or any other signs of infection immediately to your healthcare provider.
Wash your hands often.
Use an electric razor and soft toothbrush to minimize bleeding.
Avoid contact sports or activities that could cause injury.
Avoid sun exposure. Wear SPF 30 (or higher) sun block and protective clothing.
To reduce nausea, take anti-nausea medications as prescribed by your doctor, and eat small, frequent meals.
Follow regimen of anti-diarrhea medication as prescribed by your health care professional.
Eat foods that may help reduce diarrhea (see managing side effects - diarrhea)
To help treat/prevent mouth sores, use a soft toothbrush, and rinse at least three times a day with 1/2 to 1 teaspoon of baking soda and/or salt in 8 ounces of water.
In general, drinking alcoholic beverages should be minimized or avoided. You should discuss this with your doctor.
Get plenty of rest
Maintain good nutrition
Remain active as your are able. Gentle exercise is encouraged such as daily walks
Use caution when driving or engaging in tasks that require alertness until response to the drug is known.
If you experience symptoms or side effects, be sure to discuss them with your health care team. They can prescribe medications and/or offer other suggestions that are effective in managing such problems.
Monitoring and Testing While Taking Vinblastine Sulfate(casno.143-67-9):
You will be checked regularly by your doctor while you are taking Vinblastine Sulfate(casno.143-67-9), to monitor side effects and check your response to therapy. Periodic blood work will be obtained to monitor your complete blood count (CBC) as well as the function of other organs (such as your kidneys and liver) will also be ordered by your doctor.
How Vinblastine Sulfate(casno.143-67-9) works:
Cancerous tumors are characterized by cell division, which is no longer controlled as it is in normal tissue. "Normal" cells stop dividing when they come into contact with like cells, a mechanism known as contact inhibition. Cancerous cells lose this ability. Cancer cells no longer have the normal checks and balances in place that control and limit cell division. The process of cell division, whether normal or cancerous cells, is through the cell cycle. The cell cycle goes from the resting phase, through active growing phases, and then to mitosis (division).
The ability of chemotherapy to kill cancer cells depends on its ability to halt cell division. Usually, the drugs work by damaging the RNA or DNA that tells the cell how to copy itself in division. If the cells are unable to divide, they die. The faster the cells are dividing, the more likely it is that chemotherapy will kill the cells, causing the tumor to shrink. They also induce cell suicide (self-death or apoptosis).
Chemotherapy drugs that affect cells only when they are dividing are called cell-cycle specific. Chemotherapy drugs that affect cells when they are at rest are called cell-cycle non-specific. The scheduling of chemotherapy is set based on the type of cells, rate at which they divide, and the time at which a given drug is likely to be effective. This is why chemotherapy is typically given in cycles.
Chemotherapy is most effective at killing cells that are rapidly dividing. Unfortunately, chemotherapy does not know the difference between the cancerous cells and the normal cells. The "normal" cells will grow back and be healthy but in the meantime, side effects occur. The "normal" cells most commonly affected by chemotherapy are the blood cells, the cells in the mouth, stomach and bowel, and the hair follicles; resulting in low blood counts, mouth sores, nausea, diarrhea, and/or hair loss. Different drugs may affect different part of the body.
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Vinblastine Sulfate(casno.143-67-9) belongs to a class of chemotherapy drugs called alkaloids. Plant alkaloids are made from plants. The vinca alkaloids are made from the periwinkle plant (catharanthus rosea). The plant alkaloids are cell-cycle specific. This means they attack the cells during various phases of division.
Vinca alkaloids: Vincristine, Vinblastine Sulfate(casno.143-67-9) and Vinorelbine
Antimicrotubule agents (such as Vinblastine Sulfate(casno.143-67-9)), inhibit the microtubule structures within the cell. Microtubules are part of the cell's apparatus for dividing and replicating itself. Inhibition of these structures ultimately results in cell death.
Note: We strongly encourage you to talk with your health care professional about your specific medical condition and treatments. The information contained in this website is meant to be helpful and educational, but is not a substitute for medical advice.
Isolation and synthesis of Vinblastine Sulfate(casno.143-67-9):
Vinblastine Sulfate(casno.143-67-9) may be isolated from the Madagascar Periwinkle (Catharanthus roseus), along with several of its precursors- catharanthine and vindoline. Extraction is costly and yields of Vinblastine Sulfate(casno.143-67-9) and its precursors are low, although procedures for rapid isolation with improved yields avoiding auto-oxidation have been developed. Enantioselective synthesis has been of considerable interest in recent years, as the natural mixture of isomers is not an economical source for the required C16’S, C14’R stereochemistry of biologically active Vinblastine Sulfate(casno.143-67-9). Initially, the approach depends upon an enantioselective Sharpless epoxidation, which sets the stereochemistry at C20. The desired configuration around C16 and C14 can then be fixed during the ensuing steps. In this pathway, Vinblastine Sulfate(casno.143-67-9) is constructed by a series of cyclization and coupling reactions which create the required stereochemistry. The overall yield may be as great as 22%, which makes this synthetic approach more attractive than extraction from natural sources, whose overall yield is about 10%. Stereochemistry is controlled through a mixture of chiral agents (Sharpless catalysts), and reaction conditions (temperature, and selected enantiopure starting materials).
History of Vinblastine Sulfate(casno.143-67-9):
Vinblastine Sulfate(casno.143-67-9) was first isolated by Robert Noble and Charles Thomas Beer at the University of Western Ontario from the Madagascar periwinkle plant. Vinblastine Sulfate(casno.143-67-9)'s utility as a chemotherapeutic agent was first suggested by its effect on the body when an extract of the plant was injected in rabbits to study the plant's supposed anti-diabetic effect. (A tea made from the plant was a folk-remedy for diabetes.) The rabbits succumbed to a bacterial infection, due to a decreased number of white blood cells, so it was hypothesized that Vinblastine Sulfate(casno.143-67-9) might be effective against cancers of the white blood cells such as lymphoma.